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KMID : 0368019840070010037
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Journal of Soonchunhyang University
1984 Volume.7 No. 1 p.37 ~ p.43
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Studies on the Plasma Arginin Vasoprssin and Water metabnolism
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Abstract
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In order to studying the water balance in brain disease and liver cirrhosis. 15normal control subjects, 10 patients of liver cirrhosis and 20 patients of brain disease were subjected to determine plasma AVP levels by sensitive radioimmuno assay and simultaneous determined plasma and urine osmolality, Results were.
1. Plasma AVP concentration in raodomly hydrated normal adult control was average 2.0 pg/ml with range of 0.4?5.6pg/ml: Results was fairly correlated the serum osmolality and osmotic threshold was 280.4 mOsm/kg.
2, Plasma AVP level in 10 patient of liver cirrhosis was average 2.8pg/ml. with range of 0.2?9.0 and plasma and urine osmolality ratio was marked decrease in compare with normal subjects and poorly corrlated with plasma AVP and plasma osmolality.
3. Plasma AVP level in 20 patients of brain disease was average of O. 4?9. Opg/ML There are no difference of plasma level in average concentration with normal control but marked fluctuation between patients, And also poorly correlated with plasma AVP and plasma osmolality.
4. There are negligible AVP concentration and marked decreased TI/P ratio in two cases of polyuric patients.
5. Studies suggested there are more complex osmotic, nonosmotic stimuli and inhlbitor-y stimuli affected in liver cirrhosis and brain disease.
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KEYWORD
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